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International Journal of Childhood and Development Disorders
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P-ISSN: 2710-3935, E-ISSN: 2710-3943

2021, Vol. 2, Issue 1, Part A

Atypical presentation of langerhans cell histiocytosis


Author(s): Gary Saul Naficy

Abstract: A 4-year-old male from Guinea-Bissau presented with a 3-year history of a painless, progressively enlarging bilateral cervical mass (Figure 1). There was no failure to thrive, fever or any constitutional symptom. Dyspnea, dysphonia, sialorrhea and dysphagia were absent. Besides a bulky, tender bilateral cervical mass, physical exam was otherwise normal. There were no skin lesions, palpable lymphadenopathies or hepatosplenomegaly. Cervical ultrasonography showed an extensive, lobulated, solid, heterogeneous cervical mass involving cervical structures but not invading them. Contrast-enhanced cervical Computed Tomography (CT) scan revealed a multicompartmental captive lesion involving the neck, with extension to the upper and anterior mediastinum (Figure 2). Skeletal survey, chest X-ray and abdominal ultrasound were normal. Complete blood count, erythrocyte sedimentation rate, C-reactive protein, liver and kidney function and urinalysis were normal. Human Immunodeficiency Virus (HIV), cytomegalovirus, bartonellosis were excluded. The Purified Protein Derivative (PPD) test had no induration and Interferon-Gamma Release Assay (IGRA)-QuantiFERON® was negative. VCA-IgG and EBNA antibodies for Epstein-Barr virus were positive and VCA-IgM was negative.

Pages: 07-09 | Views: 1262 | Downloads: 609

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International Journal of Childhood and Development Disorders
How to cite this article:
Gary Saul Naficy. Atypical presentation of langerhans cell histiocytosis. International Journal of Childhood and Development Disorders. 2021; 2(1): 07-09.
International Journal of Childhood and Development Disorders
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