2025, Vol. 5, Issue 2, Part A
The role of vasopressin (VP) and oxytocin (OT) in autism: A potential treatment targets for the disease. (A review)
Author(s): Peter O Opara, Emeka S Asiwe, Augustus K Ahamefule, Uchechi E Enenebeaku, Uchechukwu B Nkwocha and Assumpta U Ugenyi
Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social interaction, communication, and repetitive behaviors. The potential therapeutic uses of neuropeptides, especially oxytocin and vasopressin, in treating some of the primary symptoms linked to ASD have drawn more attention in recent years. The brain produces the peptides oxytocin (OT) and arginine-vasopressin (AVP), which are then released into the peripheral bloodstream via the pituitary gland. These peptides serve a variety of physiological purposes. It has become evident in recent years that these peptides also have a major impact on how the brain regulates social behavior in mammals. Numerous lines of evidence point to their role in autism spectrum disorder (ASD), which is linked to social cognition and behavior impairments. As a result, recent clinical trials on both animal and human models of AVP administration have reported promising results in improving social cognition and behavior, and communication which are impaired in autistic patients, therefore, Male susceptibility to ASD may be exacerbated by excessive VP or disturbances in the VP system. Alternatively, the comparatively rare incidence of ASD in females may be explained by protective mechanisms mediated by OT or the OT receptor. These findings imply that AVP is a potentially useful therapeutic target to improve social cognition in individuals with autism.
DOI: 10.22271/27103919.2025.v5.i2a.51
Pages: 05-12 | Views: 236 | Downloads: 72
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How to cite this article:
Peter O Opara, Emeka S Asiwe, Augustus K Ahamefule, Uchechi E Enenebeaku, Uchechukwu B Nkwocha and Assumpta U Ugenyi. The role of vasopressin (VP) and oxytocin (OT) in autism: A potential treatment targets for the disease. (A review). International Journal of Autism. 2025; 5(2): 05-12. DOI: 10.22271/27103919.2025.v5.i2a.51
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